In Vivo Detection of Brain Krebs Cycle Intermediate by Hyperpolarized Magnetic Resonance
نویسندگان
چکیده
منابع مشابه
In vivo detection of brain Krebs cycle intermediate by hyperpolarized magnetic resonance.
The Krebs (or tricarboxylic acid (TCA)) cycle has a central role in the regulation of brain energy regulation and metabolism, yet brain TCA cycle intermediates have never been directly detected in vivo. This study reports the first direct in vivo observation of a TCA cycle intermediate in intact brain, namely, 2-oxoglutarate, a key biomolecule connecting metabolism to neuronal activity. Our obs...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 2012
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.2012.136